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O6-Benzylguanine

HY-W002585
MedChem Express
CAS Number19916-73-5
DownloadMSDS
Product group Chemicals
Estimated Purity99.97
Molecular Weight241.254
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Overview

  • Supplier
    MedChem Express
  • Product Name
    O6-Benzylguanine [19916-73-5]
  • Delivery Days Customer
    9
  • CAS Number
    19916-73-5
  • Certification
    Research Use Only
  • Estimated Purity
    99.97
  • Molecular Formula
    C12H11N5O
  • Molecular Weight
    241.254
  • Scientific Description
    O6-Benzylguanine, a guanine analog, is the DNA repair enzyme O6-alkylguanine-DNA alkyltransferase (MGMT/AGT) inhibitor. O6-Benzylguanine acts as an AGT substrate, which transfers its benzyl group to the AGT cysteine residue, thereby irreversibly inactivating AGT and preventing DNA repair. O6-Benzylguanine induces tumor cell apoptosis. Antineoplastic activity [1] [2] .
  • SMILES
    NC(N=C1OCC2=CC=CC=C2)=NC3=C1NC=N3
  • Storage Instruction
    RT
  • UNSPSC
    12352200

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