OAS1 Antibody

Cusabio

OAS1 Antibody

20

ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

OAS1

2'-5'-oligoadenylate synthetase 1

E18/E16, IFI-4, IMD100, OIAS, OIASI, 2'-5'-oligoadenylate synthase 1, (2-5')oligo(A) synthase 1, 2',5'-oligo A synthetase 1, 2'-5'-oligoadenylate synthase 1 isoform p42, 2'-5'-oligoadenylate synthetase 1, 40/46kDa, 2'-5'-oligoisoadenylate synthetase 1, 2-5A synthase 1, 2-5A synthetase 1, E16 (2'-5') oligo A synthetase

Rabbit

IgG

2'-5'-oligoadenylate synthase 1

Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2-5-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L.

Human

-20°C or -80°C

41116161