Oclacitinib maleate

Biorbyt

Oclacitinib maleate

10

1208319-27-0

Research Use Only

C19H27N5O6S

453.512583

Oclacitinib, also known as PF03394197, is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. Oclacitinib inhibited JAK family members by 50% at concentrations (IC50 s) ranging from 10 to 99 nM and did not inhibit a panel of 38 non-JAK kinases (IC50 s > 1000 nm). Oclacitinib was most potent at inhibiting JAK1 (IC50 = 10 nm). Oclacitinib also inhibited the function of JAK1-dependent cytokines involved in allergy and inflammation (IL-2, IL-4, IL-6, and IL-13) as well as pruritus (IL-31) at IC50 s ranging from 36 to 249 nM.

S(CC1CCC(CC1)N(C)C1C2C=CNC=2N=CN=1)(NC)(=O)=O.OC(/C=C\C(=O)O)=O

12352200