Olomoucine II [500735-47-7]

TargetMol Chemicals

Olomoucine II [500735-47-7]

44

500735-47-7

Research Use Only

Olomoucine II

C19H26N6O2

370.45

Olomoucine II is an inhibitor of cyclin-dependent kinases (CDKs; IC50s = 7.6, 0.1, 19.8, 0.45, and 0.06 microM for Cdk1, -2, -4, -7, and -9, respectively).1It is selective for CDKs over 10 additional kinases (IC50s = >100 microM for all) but does inhibit ERK2 (IC50= 32 microM) and the ATP-binding cassette transporter B1 (ABCB1; IC50= 6.4 microM).1,2Olomoucine II inhibits proliferation of a variety of cancer cells, including those expressing wild-type p53 or mutant p53 (mean IC50s = 7.4 and 10.1 microM, respectively), and it acts synergistically with daunorubicin to inhibit proliferation of HCT-8 cells that endogenously express ABCB1. Olomoucine also inhibits replication of herpes simplex virus 1 (HSV-1), HSV-2, vaccinia virus, human adenovirus type 4 (Ad4), and human CMV (IC50s = 5, 4.7, 3.8, 2.4, and 3.2 microM, respectively) but not measles virus or influenza virus (IC50s = >20 microM for both).3

3 years

C(C)(C)N1C=2C(=C(NCC3=C(O)C=CC=C3)N=C(N[C@H](CC)CO)N2)N=C1

-20°C

12352200