Olverembatinib (dimesylate)

MedChem Express

Olverembatinib (dimesylate) [1421783-64-3]

10

1421783-64-3

Research Use Only

99.81

C31H35F3N6O7S2

724.77

Olverembatinib (GZD824) dimesylate is a potent and orally active pan- Bcr-Abl inhibitor. Olverembatinib dimesylate potently inhibits a broad spectrum of Bcr-Abl mutants. Olverembatinib dimesylate strongly inhibits native Bcr-Abl and Bcr-Abl T315I with IC 50 s of 0.34 nM and 0.68 nM, respectively. Olverembatinib dimesylate has antitumor activity [1] . Olverembatinib (dimesylate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

O=C(NC1=CC=C(CN2CCN(C)CC2)C(C(F)(F)F)=C1)C3=CC=C(C)C(C#CC4=CN=C(NN=C5)C5=C4)=C3.CS(=O)(O)=O.CS(=O)(O)=O

2°C to 8°C

12352200