ONC1-13B [1351185-54-0]

MedChem Express

ONC1-13B [1351185-54-0]

9

1351185-54-0

Research Use Only

C22H16F4N4O3S

492.45

ONC1-13B is a potent androgen receptor (AR) antagonist with the activity of effectively inhibiting PSA expression in prostate cancer cells. ONC1-13B can effectively inhibit PSA expression and prostate cancer cell proliferation under DHT stimulation. ONC1-13B exerts its anti-tumor effect by preventing androgen from binding to AR and its nuclear translocation[1].

O=C1[C@]2(CCOC2)N(C3=CC(F)=C(C=C3)C(NC)=O)C(N1C4=CC(C(F)(F)F)=C(C=C4)C#N)=S

12352200