Oncrasin-1

MedChem Express

Oncrasin-1 [75629-57-1]

5

75629-57-1

Research Use Only

98.16

C16H12ClNO

269.73

Oncrasin-1 is an RNA polymerase inhibitor. Oncrasin-1 suppresses the phosphorylation of the largest subunit of RNA polymerase II and the expression of intronless reporter genes in sensitive cells. Oncrasin-1 effectively kills various human lung cancer cells with K-Ras mutations. Oncrasin-1 leads to coaggregation of PKCiota and splicing factors into megaspliceosomes. Oncrasin-1 induces malfunction in the RNA processing machinery. Oncrasin-1 is an anti-cancer agent and can therefore be studied in research for lung cancer[1][2].

O=CC1=CN(CC(C=C2)=CC=C2Cl)C3=CC=CC=C31

-20°C,2°C to 8°C

12352200