Orexin receptor antagonist 4 [2251017-69-1]

MedChem Express

Orexin receptor antagonist 4 [2251017-69-1]

10

2251017-69-1

Research Use Only

C23H25FN4O2

408.47

Orexin receptor antagonist 4 is potent and selective orexin 2 receptor (OX2R) antagonist with an IC50 of 4.27 nM. Orexin receptor antagonist 4 is 61-fold selective for the OX2R over the OX1R (IC50 of 295 nM) (WO2018206959A1; example 1)[1].

[H][C@@]12CN(C[C@@]1(CN([C@H]2C)C(C3=CC=C(C=C3F)OC)=O)[H])C4=NC(C)=C(C(C)=C4)C#N

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