Immunofluorescence staining of Hela cells with CSB-PA017254LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

OSBP Antibody

CSB-PA017254LA01HU

ApplicationsImmunoFluorescence, ELISA

Product group Antibodies

TargetOSBP

Overview

Supplier
Cusabio
Product Name
OSBP Antibody
Delivery Days Customer
20
Applications
ImmunoFluorescence, ELISA
Certification
Research Use Only
Clonality
Polyclonal
Conjugate
Unconjugated
Gene ID5007
Target name
OSBP
Target description
oxysterol binding protein
Target synonyms
OSBP1; oxysterol-binding protein 1
Host
Rabbit
Isotype
IgG
Protein IDP22059
Protein Name
Oxysterol-binding protein 1
Scientific Description
Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability (PubMed:18450749).
Storage Instruction
-20°C or -80°C
UNSPSC
12352203

OSBP Antibody

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Overview

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