OSI-027

MedChem Express

OSI-027 [936890-98-1]

10

936890-98-1

99.40

C21H22N6O3

406.44

OSI-027 (ASP7486) is a potent, selective, orally active and ATP-competitive mTOR kinase activity inhibitor with an IC 50 of 4 nM. OSI-027 targets both mTORC1 and mTORC2 with IC 50 s of 22 nM and 65 nM, respectively [1] [2] .

O=C([C@H]1CC[C@H](C2=NC(C(N3)=CC4=C3C(OC)=CC=C4)=C5C(N)=NC=NN52)CC1)O

-20°C

12352200