IHC image of CSB-PA753588LA01HU diluted at 1:400 and staining in paraffin-embedded human appendix tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
IHC image of CSB-PA753588LA01HU diluted at 1:400 and staining in paraffin-embedded human appendix tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
OTUD7B Antibody
CSB-PA753588LA01HU
ApplicationsImmunoFluorescence, ELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetOTUD7B
Overview
- SupplierCusabio
- Product NameOTUD7B Antibody
- Delivery Days Customer20
- ApplicationsImmunoFluorescence, ELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID56957
- Target nameOTUD7B
- Target descriptionOTU deubiquitinase 7B
- Target synonymsCEZANNE, ZA20D1, OTU domain-containing protein 7B, OTU domain containing 7B, cellular zinc finger anti-NF-kappa-B protein, cellular zinc finger anti-NF-kappaB Cezanne, zinc finger A20 domain-containing protein 1, zinc finger protein Cezanne, zinc finger, A20 domain containing 1
- HostRabbit
- IsotypeIgG
- Protein IDQ6GQQ9
- Protein NameOTU domain-containing protein 7B
- Scientific DescriptionNegative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates Lys-48-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward Lys-11, Lys-48 and Lys-63-linked polyubiquitin chains (PubMed:27732584). Has a much higher catalytic rate with Lys-11-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin.
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC41116161
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