Oxaprozin [21256-18-8]

MedChem Express

Oxaprozin [21256-18-8]

10

21256-18-8

Research Use Only

99.94

C18H15NO3

293.32

Oxaprozin is an orally active and potent COX inhibitor, with IC50 values of 2.2 microM for human platelet COX-1 and and 36 microM for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of NF-kappaB. Oxaprozin induces cell apoptosis. Oxaprozin shows anti-inflammatory activity. Oxaprozin-mediated inhibition of the Akt/IKK/NF-kappaB pathway contributes to its anti-inflammatory properties[1][2].

O=C(O)CCC1=NC(C2=CC=CC=C2)=C(C3=CC=CC=C3)O1

-20°C,2°C to 8°C

12352200