Oxaprozin-d10
HY-W709448
Molecular Weight303.38
Product group Chemicals
Overview
- SupplierMedChem Express
- Product NameOxaprozin-d10
- Delivery Days Customer999
- CertificationResearch Use Only
- Molecular FormulaC18H5D10NO3
- Molecular Weight303.38
- Scientific DescriptionOxaprozin-d10 (Oxaprozinum-d10; Wy21743-d10) is the deuterium labeled Oxaprozin (HY-B0808). Oxaprozin is an orally active and potent COX inhibitor, with IC50 values of 2.2 microM for human platelet COX-1 and and 36 microM for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of NF-kappaB. Oxaprozin induces cell apoptosis. Oxaprozin shows anti-inflammatory activity. Oxaprozin-mediated inhibition of the Akt/IKK/NF-kappaB pathway contributes to its anti-inflammatory properties[1][2].
- SMILES[2H]C1=C(C([2H])=C(C([2H])=C1C2=C(OC(CCC(O)=O)=N2)C3=C(C([2H])=C(C([2H])=C3[2H])[2H])[2H])[2H])[2H]
- UNSPSC12352200