Oxodipine [90729-41-2]

MedChem Express

Oxodipine [90729-41-2]

5

90729-41-2

Research Use Only

C19H21NO6

359.37

Oxodipine, a dihydropyridine-type calcium antagonist, inhibits KCl-induced aortic contraction in rabbits and reduces cardiac force in less potent rat ventricular test-paper contractions. In rat cultured neonatal ventricular myocytes, Oxodipine reduces L-type Ca currents (I) with an IC50 of 0.24 microM, and against T-type Ca currents (I) with an IC50 of 0.41 microM. Oxodipine causes constipation in mice and gingival hyperplasia in dogs[1][2][3][4][5][6].

CCOC(C1=C(C)NC(C)=C(C(OC)=O)C1C2=CC=CC3=C2OCO3)=O

12352200