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oYo-Link® VcMMAF Product Icon
oYo-Link® VcMMAF Product Icon
oYo-Link® VcMMAF Product Icon

oYo-Link mIgG1 VcMMAF Antibody Labeling Reagent - Labels 1mg mIgG1 Ab

Research Use Only
at7003-migg1
AlphaThera
Product group Antibodies
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    AlphaThera
  • Product Name
    oYo-Link mIgG1 VcMMAF Antibody Labeling Reagent - Labels 1mg mIgG1 Ab
  • Delivery Days Customer
    9
  • Applications Supplier
    Cell Killing Assays; Cytotoxicity assays
  • Certification
    Research Use Only
  • Concentration
    270 ug/mL
  • Format
    Dried pellet
  • Scientific Description
    Research Use Only Application: Antibody conjugation Kit for Targeted cell death; Targeted cell death for cancer cells; High-throughput screening with cell killing assays oYo-Link VcMMAF is an Antibody-Drug Conjugation Kit allowing for site-specific labeling of Monomethyl Auristatin F. labels to the heavy-chains of oYo-Link-compatible antibodies with up to two labels per antibody. VcMMAF is an anti-mitotic agent linked via the lysosomally cleavable dipeptide, valine-citrulline (vc). oYo-Link limits the attachment of the VcMMAF drugs to the heavy chains of the antibody and therefore ensures that the drug label does not interfere with antibody binding. Furthermore, site-specific labeling limits 1-2 VcMMAF drugs to be attached per antibody, providing precise antibody-drug conjugate ratios. The antibody labeling procedure simply requires mixing oYo-Link VcMMAF with the desired antibody followed by photocrosslinking with non-damaging black light (365 nm). Photocrosslinking can be carried in most buffers, including those containing amine-containing molecules (e.g. TRIS, glycine) or storage proteins (see Buffer Compatibility Table). Catalog # AT7003 Requirements: To label your compatible antibodies with oYo-Link, you will need a Light Source emitting at 365nm (6-10W). Use your own Compatible Device from our list or purchase AlphaThera's LED Photo-Crosslinking Device. Technical Support: For science questions or questions concerning compatibility email support@alphathera.com
  • Storage Instruction
    4°C for short-term durations (< 1 week) and -20°C to -80°C for longer time-spans
  • UNSPSC
    12352203