P-gb-IN-1 [2632874-49-6]

MedChem Express

P-gb-IN-1 [2632874-49-6]

14

2632874-49-6

Research Use Only

C30H28N2O6

512.55

P-gb-IN-1 (compound III-8), a 2,5-disubstituted furan derivative, is a highly effective, broadspectrum P-glycoprotein (P-gp) inhibitor. P-gb-IN-1 displayed the reversal activity by inhibiting P-gp efflux. P-gb-IN-1 has a potent affinity to P-gp by forming H-bond interactions with residues Asn 721 and Met 986. P-gb-IN-1 possesses broad-spectrum reversal activity and low toxicity in MCF-7/ADR cells[1].

O=C(NC1=CC=C(C2=CC=C(C(N3CCC(C=C(OC)C(OC)=C4)=C4C3)=O)O2)C=C1)C5=CC=C(OC)C=C5

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