Immunohistochemistry of paraffinembedded Rat liver using p16 Polyclonal Antibody at dilution of 1:100
Immunohistochemistry of paraffinembedded Rat liver using p16 Polyclonal Antibody at dilution of 1:100
p16 Polyclonal Antibody
E-AB-40264
Product group Antibodies
Overview
- SupplierElabscience
- Product Namep16 Polyclonal Antibody
- Delivery Days Customer12
- CertificationResearch Use Only
- Scientific DescriptionThis gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53.
- UNSPSC12352203