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P22077

Research Use Only
27712
BPS Bioscience
CAS Number1247819-59-5
Product group Chemicals
Estimated Purity≥98%
Molecular Weight315.3 Da
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Overview

  • Supplier
    BPS Bioscience
  • Product Name
    P22077
  • Delivery Days Customer
    7
  • CAS Number
    1247819-59-5
  • Certification
    Research Use Only
  • Estimated Purity
    ≥98%
  • Molecular Formula
    C12H7F2NO3S2
  • Molecular Weight
    315.3 Da
  • Scientific Description
    P22077 is a cell permeable inhibitor of the ubiquitin-specific protease USP7 (IC50=8.6 microM), and the closely related deubiquitinase (DUB) USP47. P22077 showed weak or no inhibition (EC50 >50microM) towards a panel of 14 isopeptidases and other proteases. Treatment of cells with P22077 (20-40 microM) causes an accumulation of K48-linked ubiquitinated species, and down regulation of the USP7 targets HDM2 and claspin.
  • UNSPSC
    12352200