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ProductsBack/p37 antibody [1320]

p37 antibody [1320]

GTX70285
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Product group Antibodies
TargetRFC4
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Overview

  • Supplier
    GeneTex
  • Product Name
    p37 antibody [1320]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    1320
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID5984
  • Target name
    RFC4
  • Target description
    replication factor C subunit 4
  • Target synonyms
    A1, MRMNS, RFC37, replication factor C subunit 4, A1 37 kDa subunit, RF-C 37 kDa subunit, RFC 37 kDa subunit, activator 1 37 kDa subunit, activator 1 subunit 4, replication factor C (activator 1) 4, 37kDa, replication factor C 37 kDa subunit
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDP35249
  • Protein Name
    Replication factor C subunit 4
  • Scientific Description
    The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Wei L, Ploss A. Hepatitis B virus cccDNA is formed through distinct repair processes of each strand. Nat Commun. 2021,12(1):1591. doi: 10.1038/s41467-021-21850-9
    Read this paper
  • Wei L, Ploss A. Core components of DNA lagging strand synthesis machinery are essential for hepatitis B virus cccDNA formation. Nat Microbiol. 2020,5(5):715-726. doi: 10.1038/s41564-020-0678-0
    Read this paper
  • Guo Z, Zheng L, Dai H, et al. Human DNA polymerase beta polymorphism, Arg137Gln, impairs its polymerase activity and interaction with PCNA and the cellular base excision repair capacity. Nucleic Acids Res. 2009,37(10):3431-41. doi: 10.1093/nar/gkp201
    Read this paper
  • Levin DS, Vijayakumar S, Liu X, et al. A conserved interaction between the replicative clamp loader and DNA ligase in eukaryotes: implications for Okazaki fragment joining. J Biol Chem. 2004,279(53):55196-201.
    Read this paper

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