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ProductsBack/p37 antibody [1320]

p37 antibody [1320]

Research Use Only
GTX70285
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse
TargetRFC4
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Overview

  • Supplier
    GeneTex
  • Product Name
    p37 antibody [1320]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    1320
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Formulation
    Liquid
  • Gene ID5984
  • Target name
    RFC4
  • Target description
    replication factor C subunit 4
  • Target synonyms
    A1; A1 37 kDa subunit; activator 1 37 kDa subunit; activator 1 subunit 4; replication factor C (activator 1) 4, 37kDa; replication factor C 37 kDa subunit; replication factor C subunit 4; RFC 37 kDa subunit; RF-C 37 kDa subunit; RFC37
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDP35249
  • Protein Name
    Replication factor C subunit 4
  • Scientific Description
    The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Hepatitis B virus cccDNA is formed through distinct repair processes of each strand. Wei L et al., 2021 Mar 11, Nat Commun
    Read more
  • Core components of DNA lagging strand synthesis machinery are essential for hepatitis B virus cccDNA formation. Wei L et al., 2020 May, Nat Microbiol
    Read more
  • Human DNA polymerase beta polymorphism, Arg137Gln, impairs its polymerase activity and interaction with PCNA and the cellular base excision repair capacity. Guo Z et al., 2009 Jun, Nucleic Acids Res
    Read more
  • A conserved interaction between the replicative clamp loader and DNA ligase in eukaryotes: implications for Okazaki fragment joining. Levin DS et al., 2004 Dec 31, J Biol Chem
    Read more