p38alpha-IN-9

MedChem Express

p38alpha-IN-9

5

Research Use Only

C27H24FN3O3

457.50

p38alpha-IN-9 (Compound 2015) is a p38alpha inhibitor and blocks p38alphas enzymatic activity with an IC50 lower than 20 nM. p38alpha-IN-9 inhibits MK2T334 phosphorylation. p38alpha-IN-9 activates Cdc25b and Cdc25c and simultaneously inactivates Wee1, leading to mitotic catastrophe, aneuploidy or polyploidy and DNA damage. p38alpha-IN-9 Inhibits colorectal cancer (CRC) metastasis[1].

CNC(C1=CC=C2C(C(C(C=CC(NC3=CC=C(F)C(NC(C4CC4)=O)=C3)=C5)=C5CC2)=O)=C1)=O

12352200