p53 Activator 2 [2338764-89-7]

MedChem Express

p53 Activator 2 [2338764-89-7]

10

2338764-89-7

Research Use Only

C20H21N5O2

363.41

p53 Activator 2 (compound 10ah) intercalats into DNA and results in significant DNA double-strand break.p53 Activator 2 increases the expression of p53, p-p53, CDK4, p21 to cause cell cycle arrest at G2/M phase.p53 Activator 2 induce apoptosis and significantly down-regulates the anti-apoptosis proteins Bcl-2, Bcl-xL and the levels of cyclin B1.p53 Activator 2 has anti-proliferation activity against MGC-803 cells, with an IC50 of 1.73 microM. p53 Activator 2 displays potent anticancer efficiency against MGC-803 xenograft tumors models[1].

NCCCCNC1=NC(/C=C/C2=CC=C([N+]([O-])=O)C=C2)=NC3=C1C=CC=C3

12131703