p53R2 peptide

GeneTex

p53R2 peptide

9

The peptide is used for blocking the antibody activity of anti-p53R2 (cat. no 8105). It usually blocks the antibody activity completely in Western blot by incubating the peptide with equal volume of antibody for 30 min at 37C.

Neutralisation/Blocking

Research Use Only

0.20 mg/ml

Unconjugated

RRM2B

ribonucleotide reductase regulatory TP53 inducible subunit M2B

MTDPS8A, MTDPS8B, P53R2, RCDFRD, ribonucleoside-diphosphate reductase subunit M2 B, TP53-inducible ribonucleotide reductase M2 B, p53-inducible ribonucleotide reductase small subunit 2 homolog, p53-inducible ribonucleotide reductase small subunit 2 short form beta, p53-inducible ribonucleotide reductase small subunit 2-like protein, ribonucleotide reductase M2 B (TP53 inducible)

The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 signaling, including p53R2, Chk2, p53AIP1, Noxa, PIDD, and PID/MTA2, were recently discovered. p53R2 is a p53 inducible gene that contains a p53 binding sequence and encodes a subunit of the enzyme ribonucleotide reductase. p53R2 is induced by ultraviolet and g-irradiation that cause DNA damage. The product of p53R2 gene is directly involved in the p53 checkpoint for repair of damaged DNA. The isoform of the p53 family member p73 also induces p53R2 expression. p53R2 is an important target of p53 for tumour suppression.

-20°C

41116100

Human