P62-mediated mitophagy inducer

MedChem Express

P62-mediated mitophagy inducer [1809031-84-2]

10

1809031-84-2

Research Use Only

99.54

C14H9IN4O2

392.15

P62-mediated mitophagy inducer (PMI) is a P62-mediated mitophagy activator. P62-mediated mitophagy inducer activates mitochondrial autophagy without recruitment of Parkin or collapse of the mitochondrial membrane potential and remains active in cells lacking a fully functional PINK1/Parkin pathway. P62-mediated mitophagy inducer serves as a pharmacological tool to study the molecular mechanisms of mitosis, avoiding toxicity and some of the non-specific effects associated with the sudden dissipation of mitochondria lacking membrane potential[1].

O=[N+](C1=CC(C2=CN(C3=CC=CC(I)=C3)N=N2)=CC=C1)[O-]

-20°C

12352200