PACMA 31

MedChem Express

PACMA 31 [1401089-31-3]

10

1401089-31-3

Research Use Only

99.32

C21H22N2O6S

430.47

PACMA 31 is an irreversible, orally active protein disulfide isomerase (PDI) inhibitor with an IC 50 of 10 microM. PACMA 31 forms a covalent bond with the active site cysteines of PDI. PACMA 31 shows tumor targeting ability and significantly suppresses ovarian tumor growth without causing toxicity to normal tissues [1] . PACMA 31 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

COC1=CC=C(N(C(C2=CC=CS2)C(NCC(OCC)=O)=O)C(C#C)=O)C(OC)=C1

-20°C,2°C to 8°C

12352200