Pactimibe (sulfate) [608510-47-0]

MedChem Express

Pactimibe (sulfate) [608510-47-0]

10

608510-47-0

Research Use Only

98.0

C25H40N2O3.1/2H2O4S

465.65

Pactimibe sulfate (CS-505) is a dual ACAT1/2 inhibitor with IC50s of 4.9 microM and 3.0 microM, respectively. Pactimibe sulfate (CS-505) inhibits ACAT with IC50s of 2.0 microM, 2.7 microM, 4.7 microM in the liver, macrophages and THP-1 cells, respectively[1]. Pactimibe sulfate (CS-505) noncompetitively inhibits oleoyl-CoA with a Ki value of 5.6 microM. Moreover, Pactimibe sulfate (CS-505) obviously inhibits cholesteryl ester formation with an IC50 of 6.7 microM. Pactimibe sulfate (CS-505) possesses anti-atherosclerotic potential with lowering plasma cholesterol activity[2].

O=C(O)CC1=C(C)C2=C(N(CCCCCCCC)CC2)C(NC(C(C)(C)C)=O)=C1C.O=S(O)(O)=O.[1/2]

2°C to 8°C

12352200