PAG3 antibody [N1N2], N-term

GeneTex

PAG3 antibody [N1N2], N-term

9

WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot

Research Use Only

Polyclonal

0.77 mg/ml

Unconjugated

Liquid

ASAP2

ArfGAP with SH3 domain, ankyrin repeat and PH domain 2

AMAP2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2; centaurin, beta 3; CENTB3; DDEF2; development and differentiation-enhancing factor 2; PAG3; PAP; Pap-alpha; paxillin-associated protein with ARF GAP activity 3; PYK2 C terminus-associated protein; pyk2 C-terminus-associated protein; SHAG1

Rabbit

IgG

Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2

This gene encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II ArfGAPs in vitro, and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle budding when recruited to Golgi membranes. In addition, it functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Human, Mouse

-20°C or -80°C,2°C to 8°C

12352203