Pamidronate (disodium)

MedChem Express

Pamidronate (disodium) [57248-88-1]

5

57248-88-1

Research Use Only

98.0

C3H9NNa2O7P2

279.03

Pamidronate disodium, the second-generation nitrogen-containing bisphosphonate, is an inhibitor of bone loss. Pamidronate disodium significantly inhibits subchondral bone loss in early osteoarthritis by upregulating the expression of OPG in cartilage and subchondral bone, and inhibiting the expression of RANKL and MMP-9 in both tissues, as well as TLR-4 in cartilage, thereby alleviating cartilage degeneration. Additionally, Pamidronate disodium can inhibit the signaling of Wnt and beta-catenin , and is applicable for research on osteoporosis and osteosarcoma [1] [2] [3] [4] .

OP(C(O)(P(O)(O[Na])=O)CCN)(O[Na])=O

2°C to 8°C

12352200