Immunofluorescent analysis of PC-3 cells using CSB-PA773045LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

PARG Antibody

CSB-PA773045LA01HU

ApplicationsImmunoFluorescence, ELISA

Product group Antibodies

ReactivityHuman

TargetBPHL

Overview

Supplier
Cusabio
Product Name
PARG Antibody
Delivery Days Customer
20
Applications
ImmunoFluorescence, ELISA
Certification
Research Use Only
Clonality
Polyclonal
Conjugate
Unconjugated
Gene ID670
Target name
BPHL
Target description
biphenyl hydrolase like
Target synonyms
BPH-RP, MCNAA, VACVASE, serine hydrolase BPHL, L-homocysteine-thiolactonase BPHL, biphenyl hydrolase-like (serine hydrolase), biphenyl hydrolase-related protein, breast epithelial mucin-associated antigen, valacyclovir hydrolase, valacyclovirase
Host
Rabbit
Isotype
IgG
Protein IDQ86W56
Protein Name
Poly(ADP-ribose) glycohydrolase
Scientific Description
Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase (PubMed:23102699). PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers (PubMed:23102699). Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (PubMed:23102699). Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257).
Reactivity
Human
Storage Instruction
-20°C or -80°C
UNSPSC
41116161

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PARG Antibody

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