PARL antibody

GeneTex

PARL antibody

9

WB: 1 - 2 microg/mL. ICC/IF: 2.5 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

PARL

presenilin associated rhomboid like

mitochondrial intramembrane-cleaving protease PARL; presenilins-associated rhomboid-like protein, mitochondrial; PRO2207; PSARL; PSARL1; PSENIP2; RHBDS1; rhomboid 7 homolog 1

Rabbit

IgG

Presenilins-associated rhomboid-like protein, mitochondrial

PARL is a mitochondrial integral membrane protein and a member of the highly conserved rhomboid superfamily of membrane proteins. PARL is required for the control of apoptosis during postnatal growth and is required for the processing of OPA1, a protein that prevents the release of cytochrome C from the mitochondria in response to apoptotic signals. In lymphocytes and neurons, PARLs association with other proteins, such as the Bcl-2 family-related protein Hax1 and Omi can lead to the proteolytic processing of Omi by PARL, preventing the accumulation of Bax, thereby suppressing apoptosis. Variations in this gene have been associated with increased risk for type 2 diabetes. PARL may also play a role in the progression of Alzheimers disease through its associations with presenilin-1 and -2. Despite its predicted molecular weight of ~42kDa, PARL is observed at a higher molecular weight in SDS-PAGE. Multiple isoforms of PARL are known to exist.

-20°C or -80°C,2°C to 8°C

12352203