Bio-Connect

PARP-1/2-IN-2

HY-149398
MedChem Express
Molecular Weight610.41
Product group Chemicals
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Overview

  • Supplier
    MedChem Express
  • Product Name
    PARP-1/2-IN-2 [3052304-23-8]
  • Delivery Days Customer
    14
  • Certification
    Research Use Only
  • Molecular Formula
    C25H23IN8O3
  • Molecular Weight
    610.41
  • Scientific Description
    PARP-1/2-IN-2-IN-1 (Compound 12e) is a PARP1/2/CDK12 inhibitor (IC50: 34, 30 and 285 nM respectively). PARP-1/2-IN-2 inhibits DNA damage repair, promotes cell cycle arrest and apoptosis. PARP-1/2-IN-2 inhibits the growth of TNBC cells and TNBC xenograft tumor[1].
  • SMILES
    NC(C1=CC=CC2=C1N=C(NC(C3=CC(C(N4CCC(NC5=NC=C(I)C=N5)CC4)=O)=CC=C3)=O)N2)=O
  • UNSPSC
    12131703