PARP-1/2-IN-2
HY-149398
Overview
- SupplierMedChem Express
- Product NamePARP-1/2-IN-2 [3052304-23-8]
- Delivery Days Customer14
- CertificationResearch Use Only
- Molecular FormulaC25H23IN8O3
- Molecular Weight610.41
- Scientific DescriptionPARP-1/2-IN-2-IN-1 (Compound 12e) is a PARP1/2/CDK12 inhibitor (IC50: 34, 30 and 285 nM respectively). PARP-1/2-IN-2 inhibits DNA damage repair, promotes cell cycle arrest and apoptosis. PARP-1/2-IN-2 inhibits the growth of TNBC cells and TNBC xenograft tumor[1].
- SMILESNC(C1=CC=CC2=C1N=C(NC(C3=CC(C(N4CCC(NC5=NC=C(I)C=N5)CC4)=O)=CC=C3)=O)N2)=O
- UNSPSC12131703