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Chemical Structure
Chemical Structure
Chemical Structure

Parthenolide [20554-84-1]

Research Use Only
CDX-P0297
Chemodex
CAS Number20554-84-1
Product group Chemicals
Estimated Purity>98%
Molecular Weight248.32
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Overview

  • Supplier
    Chemodex
  • Product Name
    Parthenolide [20554-84-1]
  • Delivery Days Customer
    10
  • CAS Number
    20554-84-1
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Molecular Formula
    C15H20O3
  • Molecular Weight
    248.32
  • Scientific Description
    Anticancer and antiangiogenic compound. Induces apoptosis, cell cycle arrest and autophagy in various cancer cell lines. At low concentrations acts as antioxidant reducing oxidative stress generated through the TCR signaling pathway. At high concentration induces O2- and causes oxidative-stress-mediated apoptosis. Potent anti-inflammatory and anti-atherosclerotic agent. NF-kappaB inhibitor by directly targeting IkappaB kinase. NLRP3 inflammasome inhibitor. Inhibits ATPase activity of NLRP3 and protease activity of caspase 1. Specifically inhibits HDAC1 without affecting other class I/II HDACs. DNA methyltransferase 1 (DNMT1) inhibitor. Reduces the expression of VEGF and its receptors VEGRF1 and 2. Microtubule-interfering compound, inhibiting cell migration and tubule formation. Anti-leishmanial and anti-trypanosomal agent. - Chemical. CAS: 20554-84-1. Formula: C15H20O3. MW: 248.32. Synthetic. Anticancer and antiangiogenic compound. Induces apoptosis, cell cycle arrest and autophagy in various cancer cell lines. At low concentrations acts as antioxidant reducing oxidative stress generated through the TCR signaling pathway. At high concentration induces O2- and causes oxidative-stress-mediated apoptosis. Potent anti-inflammatory and anti-atherosclerotic agent. NF-kappaB inhibitor by directly targeting IkappaB kinase. NLRP3 inflammasome inhibitor. Inhibits ATPase activity of NLRP3 and protease activity of caspase 1. Specifically inhibits HDAC1 without affecting other class I/II HDACs. DNA methyltransferase 1 (DNMT1) inhibitor. Reduces the expression of VEGF and its receptors VEGRF1 and 2. Microtubule-interfering compound, inhibiting cell migration and tubule formation. Anti-leishmanial and anti-trypanosomal agent.
  • SMILES
    C/C1=C\CC[C@](O2)(C)[C@H]2[C@@H](OC(C3=C)=O)[C@H]3CC1
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352200

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