Paxilline

MedChem Express

Paxilline [57186-25-1]

9

57186-25-1

Research Use Only

99.83

C27H33NO4

435.56

Paxilline is an indole alkaloid mycotoxin derived from Penicillium paxilli, which effectively inhibits the BK channel through a channel-blocking mechanism. Paxilline also inhibits sarco/endoplasmic reticulum Ca 2+ -stimulated ATPase (SERCA) , with IC 50 values ranging from 5 microM to 50 microM for different SERCA isoforms. Paxilline exhibits significant anticonvulsant and neuroprotective effects, as well as certain antioxidant activity [1] [2] [3] [4] [5] [6] .

O=C1[C@@H](C(C)(O)C)O[C@](CC2)([H])C([C@]([C@@]2(C)[C@]34C)(O)CC[C@@]3([H])CC5=C4NC6=C5C=CC=C6)=C1

-20°C,2°C to 8°C

12352200