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PB28

HY-108511A
MedChem Express
CAS Number172906-90-0
DownloadMSDS
Product group Chemicals
Molecular Weight370.57
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Overview

  • Supplier
    MedChem Express
  • Product Name
    PB28 [172906-90-0]
  • Delivery Days Customer
    10
  • CAS Number
    172906-90-0
  • Certification
    Research Use Only
  • Molecular Formula
    C24H38N2O
  • Molecular Weight
    370.57
  • Scientific Description
    PB28 is a cyclohexylpiperazine derivative and a high affinity and selective sigma 2 (sigma2) receptor agonist with a K i of 0.68 nM. PB28 is also a sigma1 antagonist with a K i of 0.38 nM. PB28 is less affinity for other receptors. PB28 inhibits electrically evoked twitch in guinea pig bladder and ileum with EC 50 values of 2.62 microM and 3.96 microM, respectively. PB28 can modulate SARS-CoV-2-human protein-protein interaction. PB28 induces caspase-independent apoptosis and has antitumor activity [1] [2] [3] [4] [5] .
  • SMILES
    COC1=CC=CC2=C1CCCC2CCCN3CCN(C4CCCCC4)CC3
  • UNSPSC
    12352200