PC-046 [1202401-59-9]
HY-120561
CAS Number1202401-59-9
Product group Chemicals
Molecular Weight358.39
Overview
- SupplierMedChem Express
- Product NamePC-046 [1202401-59-9]
- Delivery Days Customer5
- CAS Number1202401-59-9
- CertificationResearch Use Only
- Molecular FormulaC22H18N2O3
- Molecular Weight358.39
- Scientific DescriptionPC-046 is a multi-target inhibitor for tyrosine receptor kinase B (TrkB), IRAK-4 and Pim-1, with IC50 of 13.4 microM, 15.4 microM and 19.1 microM, respectively. PC-046 exhibits cytotoxicity against pancreatic cancer cell BxPC3 with IC50 of 7.5-130 nM. PC-046 induces apoptosis and arrests cell cycle at G2/M phase in BxPC3. PC-046 exhibits antitumor efficacy and exhibits good pharmacokinetic characteristics in mice[1].
- SMILESCOC1=CC(C2=C(C=CN=C2)C3=NC=C(O3)C4=CC=C(C=C4)OC)=CC=C1
- UNSPSC12352200