PCBP1 antibody [AT2A10]

GeneTex

PCBP1 antibody [AT2A10]

9

The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended starting dilution is 1:500.

Western Blot, ELISA

Research Use Only

Monoclonal

AT2A10

1 mg/ml

Unconjugated

PCBP1

poly(rC) binding protein 1

alpha-CP1; epididymis secretory protein Li 85; HEL-S-85; heterogeneous nuclear ribonucleoprotein E1; heterogenous nuclear ribonucleoprotein E1; heterogenous nuclear ribonucleoprotein X; hnRNP-E1; hnRNP-X; HNRPE1; HNRPX; nucleic acid-binding protein SUB2.3; poly(rC)-binding protein 1

Mouse

IgG2a

Poly(rC)-binding protein 1

This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. [provided by RefSeq, Jul 2008]

Human

-20°C or -80°C,2°C to 8°C

12352203