PCGF2 Antibody

Cusabio

PCGF2 Antibody

20

ImmunoFluorescence, ELISA

Research Use Only

Polyclonal

Unconjugated

PCGF2

polycomb group ring finger 2

MEL-18, RNF110, TPFS, ZNF144, polycomb group RING finger protein 2, DNA-binding protein Mel-18, ring finger protein 110, zinc finger protein 144

Rabbit

IgG

Polycomb group RING finger protein 2

Transcriptional repressor. Binds specifically to the DNA sequence 5-GACTNGACT-3. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility. Is not functionally redundant with BMI1; unlike BMI1 does not stimulate the E3 ubiquitin-protein ligase activity in a reconstituted PRC1-like complex (By similarity).

Human

-20°C or -80°C

41116161