PD-089828

MedChem Express

PD-089828 [179343-17-0]

9

179343-17-0

Research Use Only

98.07

C18H18Cl2N6O

405.28

PD-089828 is an ATP competitive inhibitor of FGFR-1, PDGFR-beta and EGFR (IC50s=0.15, 1.76, and 5.47 microM, respectively) and a noncompetitive inhibitor of c-Src tyrosine kinase (IC50=0.18 microM). PD-089828 also inhibits MAPK with an IC50 of 7.1 microM. PD-089828 inhibits PDGF-, EGF- and bFGF-mediated tyrosine kinase receptor autophosphorylation in vitro. PD-089828 has a long-lasting cellular activity[1].

O=C(NC(C)(C)C)NC1=NC2=NC(N)=NC=C2C=C1C3=C(Cl)C=CC=C3Cl

-20°C,2°C to 8°C

12352200