PD-161570

MedChem Express

PD-161570 [192705-80-9]

5

192705-80-9

99.82

C26H35Cl2N7O

532.51

PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC 50 of 39.9 nM and a K i of 42 nM. PD-161570 also inhibits the PDGFR , EGFR and c-Src tyrosine kinases with IC 50 values of 310 nM, 240 nM, and 44 nM, respectively. PD-161570 inhibits PDGF -stimulated autophosphorylation and FGF-1 receptor phosphorylation with IC 50 s of 450 nM and 622 nM, respectively [1] [2] . PD-161570 is also a bone morphogenetic proteins (BMPs) and TGF-beta signaling inhibitor [3] .

O=C(NC(C)(C)C)NC1=NC2=NC(NCCCCN(CC)CC)=NC=C2C=C1C3=C(Cl)C=CC=C3Cl

-20°C,2°C to 8°C

12352200