PD 173074 [219580-11-7]
27056
CAS Number219580-11-7
Product group Chemicals
Estimated Purity≥99%
Molecular Weight523.7 Da
Overview
- SupplierBPS Bioscience
- Product NamePD 173074
- Delivery Days Customer7
- CAS Number219580-11-7
- CertificationResearch Use Only
- Estimated Purity≥99%
- Molecular FormulaC28H41N7O3
- Molecular Weight523.7 Da
- Scientific DescriptionPD 173074 inhibited the kinase activity of FGFR1 with an IC50 of 25 nM in vitro, while inhibiting Src, the receptors for insulin, epidermal growth factor (EGF) and PDGF, and several serine/threonine kinases with 1000-fold or higher IC50 values. PD 173074 was an ATP-competitive inhibitor of FGFR1, with a Ki of around 40 nM. PD 173074 inhibited autophosphorylation of FGFR1 and VEGFR2 in a dose-dependent manner with IC50s in the range of 1-5 nM and 100-200 nM, respectively.
- Storage Instruction-20°C
- UNSPSC51202000