PD-173955 [260415-63-2]

SYNkinase

PD-173955 [260415-63-2]

10

260415-63-2

Research Use Only

>95%

C21H16Cl2N4OS

443.4

Chemical. CAS: 260415-63-2. Formula: C21H16Cl2N4OS. MW: 443.4. PD173955 is an ATP-competitive, dual Src/Bcr-Abl kinase inhibitor. It is a potent inhibitor of Bcr-Abl with an IC(50) of 1-2nM in kinase inhibition assays. In cellular growth assays it inhibits Bcr-Abl-dependent substrate tyrosine phosphorylation. PD173955 also inhibits Src kinase activity in vitro with an IC(50) of 22nM and could represent a novel class of anti-mitotic drug. - PD173955 is an ATP-competitive, dual Src/Bcr-Abl kinase inhibitor. It is a potent inhibitor of Bcr-Abl with an IC(50) of 1-2nM in kinase inhibition assays. In cellular growth assays it inhibits Bcr-Abl-dependent substrate tyrosine phosphorylation. PD173955 also inhibits Src kinase activity in vitro with an IC(50) of 22nM and could represent a novel class of anti-mitotic drug.

2°C to 8°C

51202000