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PD-1:PD-L1 Cell-Based Inhibitor Screening Assay Kit

Research Use Only
79377
BPS Bioscience
Product group Assays
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Overview

  • Supplier
    BPS Bioscience
  • Product Name
    PD-1:PD-L1 Cell-Based Inhibitor Screening Assay Kit
  • Certification
    Research Use Only
  • Scientific Description
    The PD-1/PD-L1 Inhibitor Screening Cell-Based Assay is a bioluminescent cell-based assay that can be used to screen and profile inhibitors of the PD-1:PD-L1 interaction. The assay consists of two main components: Growth-Arrested PD-1 Effector cells (PD-1/NFAT reporter-Jurkat cells): Reporter Jurkat T cells expressing firefly luciferase gene under the control of NFAT response elements and also constitutively expressing human PD-1. These cryopreserved cells are provided in a thaw-anduse format that does not require cell propagation. These cells are modified not to be expanded and are intended to be used in a single experiment. Expression vectors for TCR activator, and Human PD-L1: Transfection-ready vectors are used to transfect cells to create the target cells that overexpress PD-L1 and an engineered cell surface T cell receptor (TCR) activator.
  • UNSPSC
    41116133