PD180970

MedChem Express

PD180970 [287204-45-9]

10

287204-45-9

Research Use Only

99.27

C21H15Cl2FN4O

429.27

PD180970 is a highly potent and ATP-competitive p210 Bcr-Abl kinase inhibitor, with an IC 50 of 5 nM for inhibiting the autophosphorylation of p210 Bcr-Abl . PD180970 also inhibits Src and KIT kinase with IC 50 s of 0.8 nM and 50 nM, respectively. PD180970 indcues apoptosis of K562 leukemic cells, and can be used for chronic myelogenous leukemia research [1] [2] [3] .

O=C1C(C2=C(Cl)C=CC=C2Cl)=CC3=CN=C(NC4=CC=C(F)C(C)=C4)N=C3N1C

-20°C,2°C to 8°C

12352200