PDCD4 (phospho Ser457) antibody [2E10.C12]

GeneTex

PDCD4 (phospho Ser457) antibody [2E10.C12]

10

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Monoclonal

2E10.C12

1 mg/ml

Mouse

IgG

Phosphorylated

Programmed cell death 4 (Pdcd4) is a novel tumor supressor. Pdcd4 directly inhibits the helicase activity of eukaryotic translation initiation factor 4A (eIF4A), a component of the translation initiation complex. Pdcd4 also suppresses the transactivation of activator protein-1 (AP-1)-responsive promoters by c-Jun. Pdcd4 contains two Akt phosphoryl-ation sites, one at Ser67 and the other at Ser457. The phosphorylation of Pdcd4 by Akt causes nuclear translocation of Pdcd4 and a significant decrease in the ability of Pdcd4 to interfere with the transactivation of AP-1-responsive promoters by c-Jun.

Human, Mouse, Rat, Xenopus

2°C to 8°C,-20°C

12352203