PDCD4 (phospho Ser457) antibody [2E10.C12]

GeneTex

PDCD4 (phospho Ser457) antibody [2E10.C12]

9

WB: 1:1000-1:3000. ELISA: 1:400000. IHC: 1.25-2.5 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ELISA, ImmunoHistoChemistry, Other Application

Research Use Only

Monoclonal

9G6

1 mg/ml

Unconjugated

PDCD4

programmed cell death 4

H731; neoplastic transformation inhibitor protein; nuclear antigen H731; programmed cell death 4 (neoplastic transformation inhibitor); programmed cell death protein 4; protein 197/15a

Mouse

IgG1

Programmed cell death protein 4

Programmed cell death 4 (Pdcd4) is a novel tumor supressor. Pdcd4 directly inhibits the helicase activity of eukaryotic translation initiation factor 4A (eIF4A), a component of the translation initiation complex. Pdcd4 also suppresses the transactivation of activator protein-1 (AP-1)-responsive promoters by c-Jun. Pdcd4 contains two Akt phosphoryl-ation sites, one at Ser67 and the other at Ser457. The phosphorylation of Pdcd4 by Akt causes nuclear translocation of Pdcd4 and a significant decrease in the ability of Pdcd4 to interfere with the transactivation of AP-1-responsive promoters by c-Jun.

-20°C or -80°C,2°C to 8°C

12352203