PDE1-IN-4

MedChem Express

PDE1-IN-4 [3031349-98-8]

10

Research Use Only

C33H33N3O4

535.63

PDE1-IN-4 (compound 2g) is a potent and selective PDE1 (phosphodiesterase-1) inhibitor, with IC50 values of 10, 145, and 354 nM for PDE1C, PDE1A, and PDE1B, respectively. PDE1-IN-4 inhibits myofibroblast differentiation of human lung fibroblasts induced by TGF-beta1. PDE1-IN-4 shows anti-fibrosis effects through the regulation of cAMP (3,5-cyclic adenosine monophosphate) and cGMP (3,5-cyclic guanosine monophosphate). PDE1-IN-4 can be used for idiopathic pulmonary fibrosis (IPF) research[1].

CC1=C(C(C2=CC3=C(C=C2)N(N=C3)C)C(C(O[C@@H](C4=CC=CC=C4)C)=O)=C(N1)C)C(O[C@@H](C5=CC=CC=C5)C)=O

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