PDE11A antibody, Internal

GeneTex

PDE11A antibody, Internal

9

This antibody is expected to recognise all four reported isoforms (NP_058649.3 ; NP_001070665.1; NP_001070826.1; NP_001070664.1).

WB: 0.5-1.5microg/ml. IHC-P: 10microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

0.50 mg/ml

Unconjugated

PDE11A

phosphodiesterase 11A

cAMP and cGMP cyclic nucleotide phosphodiesterase 11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A; PPNAD2

Goat

IgG

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

The 3,5-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3,5-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Human

-20°C or -80°C,2°C to 8°C

12352203