PDE4-IN-6

MedChem Express

PDE4-IN-6

10

Research Use Only

C25H20FNO5S

465.49

PDE4-IN-6 is a potent, safe and moderately selective PDE4 inhibitor with IC50s of 0.125 and 0.43 microM for PDE4B and PDE4D, respectively. PDE4-IN-6 can downregulate the expression level of TNF-alpha and IL-6. PDE4-IN-6 has potent immunomodulatory activity thereby its potential against rheumatoid arthritis. Anti-inflammatory and anti-arthritic effects[1].

CC(CCC1=C(OC(C2=CC(F)=CC=C21)=O)C3=CC(NS(=O)(C4=CC=CC=C4)=O)=CC=C3)=O

12352200