PDE4-IN-9 [2519450-32-7]

MedChem Express

PDE4-IN-9 [2519450-32-7]

10

2519450-32-7

Research Use Only

C15H12N4O3S

328.35

PDE4-IN-9 (Compound 5j) is a potent inhibitor of PDE4. PDE4-IN-9 exhibits lower IC50 value (1.4 microM) against PDE4 than parent rolipram (2.0 microM) in in vitro enzyme assay. PDE4-IN-9 also displays good in vivo activity in animal models of asthma/COPD and sepsis induced by LPS[1].

COC1=CC=C(C=C1)C2=NC(C(N3CCS/C3=N\C#N)=O)=CO2

12131703