PDE5-IN-2 [2244517-61-9]

MedChem Express

PDE5-IN-2 [2244517-61-9]

10

2244517-61-9

Research Use Only

C25H21N3O6S

491.52

PDE5-IN-2 is a potent, highly selective, and orally active PDE5 inhibitor, with an IC50 of 0.31 nM, less potently inhibits PDE2A, PDE10A, PDE4D2, and PDE6C, with IC50s of 106, 46, 43, 1.2 nM, respectively. Anti-pulmonary arterial hypertension activity[1].

O=C1C2=C(C3=NC=CS3)NC(CC4=CC(OCO5)=C5C=C4)=C2OC6=CC(NCCOC)=CC(O)=C61

12352200