PELP1 Recombinant Monoclonal Antibody

Cusabio

PELP1 Recombinant Monoclonal Antibody

20

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Monoclonal

6H4

Unconjugated

PELP1

proline, glutamate and leucine rich protein 1

MNAR; modulator of non-genomic activity of estrogen receptor; P160; proline and glutamic acid rich nuclear protein; proline-, glutamic acid- and leucine-rich protein 1; transcription factor HMX3

IgG

Proline-, glutamic acid- and leucine-rich protein 1

Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Involved in nuclear receptor signaling via its interaction with AR and NR3C1. May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.

-20°C or -80°C

12352203