Perfluorotetradecanoic acid [376-06-7]

MedChem Express

Perfluorotetradecanoic acid [376-06-7]

5

376-06-7

Research Use Only

98.0

C14HF27O2

714.11

Perfluorotetradecanoic acid (PFTeDA) is a PPARgamma inhibitor. Perfluorotetradecanoic acid binds to human PPARgamma ligand binding domain with IC50 of 22.8 microM, Kd of 157.8 microM. Perfluorotetradecanoic acid inhibits the function of Leydig cells by inducing oxidative stress and apoptosis. Perfluorotetradecanoic acid stimulates corticosterone biosynthesis but inhibits aldosterone production[1][2][3].

O=C(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(F)F)F)F)F)F)F)F)F)F)F)F)F)F)O

-20°C,2°C to 8°C

12352200